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BT166491
BIO-X

Sirt-IN-1

Inhibitor of pan-sirtuins (IC50 = 15, 10, 33 µM for SIRT1, 2 and 3 respectively), by binding to the active catalytic site. Selectivity for sirtuins was demonstrated when tested for activity on a panel of kinases, nuclear receptors, ion channels, transporters and GPCRs. 

Technical Data

CAS No: 1431411-60-7
Synonyms: Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-1-piperidinyl]
Product Code: BT166491
MDL No: MFCD28386339
Chemical Formula: C19H27N5O2S
Molecular Weight: 389.52

References


  • Disch JS et al (2013). Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem 56(9):3666-79.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1431411-60-7
Synonyms:
Thieno[3,2-d]pyrimidine-6-carboxamide, 4-[4-[2-[(2,2-dimethyl-1-oxopropyl)amino]ethyl]-1-piperidinyl]
MDL No:
MFCD28386339
Chemical Formula:
Molecular Weight:
389.52
Product Structure
References:
1. Disch JS et al (2013). Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem 56(9):3666-79.
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