Availability
0
Your Basket is Empty
BW170250
BIO-X

WS 383 hydrochloride NEW

Potent inhibitor of the interaction between defective cullin neddylation protein DCN1 and NEDD8-conjugating enzyme UBC12 with IC50 of 11 nM. WS 383 blocks the DCN1-UBC12 interaction in a reversible manner, selectively inhibits Cul3/1 neddylation and induces accumulation of p21, p27, and NRF2 proteins.

Technical Data

CAS No: 2247544-02-9
Product Code: BW170250
Chemical Formula: C18H20ClN9S2·HCl
Molecular Weight: 498.46

References


  • Wang et al (2019). Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5‑a]pyrimidine-Based Inhibitors Targeting the DCN1− UBC12 Protein−Protein Interaction. Journal of Medicinal Chemistry 62:2772−2797.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2247544-02-9
Chemical Formula:
Molecular Weight:
498.46
Product Structure
References:
1. Wang et al (2019). Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5‑a]pyrimidine-Based Inhibitors Targeting the DCN1− UBC12 Protein−Protein Interaction. Journal of Medicinal Chemistry 62:2772−2797.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...