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FA64936

Aloperine

Alkaloid from the plants of genus Sophora, which are used in the traditional Chinese medicine. The compound is able to arrest the cell cycle in G2/M phase and induce apoptosis in hepatocellular carcinoma and in prostate cancer models. Aloperine has anti-proliferative effects also on breast cancer cell lines and is able to supress colony formation. In addition, it has been reported that it possesses also anti-inflammatory, anti-allergenic and anti-viral properties.

Technical Data

CAS No: 56293-29-9
Product Code: FA64936
MDL No: MFCD00468086
Chemical Formula: C15H24N2
Molecular Weight: 232.36

References


  • Liu et al., 2019. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. Phytomedicine [In Press]
  • Tian et al., 2018. Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells. Molecular Medicine Reports 18(4):3699-3710.
  • Ling et al., 2018. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Oncotargets and Therapy 11: 2735–2743.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
56293-29-9
MDL No:
MFCD00468086
Chemical Formula:
Molecular Weight:
232.36
Product Structure
References:
1. Liu et al., 2019. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway. Phytomedicine [In Press]
2. Tian et al., 2018. Aloperine inhibits proliferation, migration and invasion and induces apoptosis by blocking the Ras signaling pathway in human breast cancer cells. Molecular Medicine Reports 18(4):3699-3710.
3. Ling et al., 2018. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Oncotargets and Therapy 11: 2735–2743.
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