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BJ164539

JWH 133 - Bio-X

An agonist of cannabinoid CB2 receptors. Reduces cardiac infarct size, mediated by inhibiting intrinsic mitochondria-mediated apoptosis in the myocardium during ischemia/reperfusion. Reversal of the cardioprotective activity of JWH 133 by wortmanin suggests the involvement of PI3K/Akt signalling pathway.

Technical Data

CAS No: 259869-55-1
Product Code: BJ164539
Chemical Formula: C22H32O
Molecular Weight: 312.49

References


  • Xu H et al (2007). Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol 82(3):532-41.
  • Li Q et al (2013). Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis. Cell Physiol Biochem 31(4-5):693-702.
  • López-Dyck E et al (2017). ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms. Pharmacol Rep 69(6):1131-1139.

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Further Information


Datasheets


JWH 133 - Bio-X

CAS No:
259869-55-1
Chemical Formula:
Molecular Weight:
312.49
Product Structure
References:
1. Xu H et al (2007). Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. J Leukoc Biol 82(3):532-41.
2. Li Q et al (2013). Activation of cannabinoid type 2 receptor by JWH133 protects heart against ischemia/reperfusion-induced apoptosis. Cell Physiol Biochem 31(4-5):693-702.
3. López-Dyck E et al (2017). ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent mechanisms. Pharmacol Rep 69(6):1131-1139.

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