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BG166816

GNE 140 - Bio-X

Inhibitor of lactate dehydrogenase A (LDHA), which catalyzes the conversion of pyruvate to lactate yielding NAD. The compound binds to the enzymes active site adjacent to NADH with IC50 = 3 nM. LDHA is expressed in many glycolysis-dependent tumors and its inhibition affects global cell metabolism and proliferation. 

Technical Data

CAS No: 1802977-61-2
Product Code: BG166816
Chemical Formula: C25H23ClN2O3S2
Molecular Weight: 499.05

Literature


  • Boudreau A et al., (2016). Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol 12(10):779-86.

Solubility

Stability

Further Information


Datasheets


GNE 140 - Bio-X

CAS No:
1802977-61-2
Chemical Formula:
Molecular Weight:
499.05
Product Structure
References:
1. Boudreau A et al., (2016). Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition. Nat Chem Biol 12(10):779-86.

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