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FA65034
BIO-X

Dabrafenib

Inhibitor of mutant B-rafV600E protein that results in decreased proliferation of cancer cells with this mutation. Treatment of metastatic melanoma in patients harboring the V600E mutation, had improved disease outcome. This antitumor activity is enhanced when combined with MEK inhibitor trametinib.

Technical Data

CAS No: 1195765-45-7
Synonyms: N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide; GSK2118436A
Product Code: FA65034
MDL No: MFCD17215684
Chemical Formula: C23H20F3N5O2S2
Molecular Weight: 519.56

References


  • Rheault TR et al (2013). Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors. ACS Med Chem Lett 4(3):358-62.
  • Banzi M et al (2016). Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma. Onco Targets Ther 9:2725-33.
  • Spain L et al (2016). Combination dabrafenib and trametinib in the management of advanced melanoma with BRAFV600 mutations. Expert Opin Pharmacother 17(7):1031-8.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1195765-45-7
Synonyms:
N-(3-(5-(2-Aminopyrimidine-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
GSK2118436A
MDL No:
MFCD17215684
Chemical Formula:
Molecular Weight:
519.56
Product Structure
References:
1. Rheault TR et al (2013). Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors. ACS Med Chem Lett 4(3):358-62.
2. Banzi M et al (2016). Dabrafenib: a new opportunity for the treatment of BRAF V600-positive melanoma. Onco Targets Ther 9:2725-33.
3. Spain L et al (2016). Combination dabrafenib and trametinib in the management of advanced melanoma with BRAFV600 mutations. Expert Opin Pharmacother 17(7):1031-8.
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