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BA162794
BIO-X

A 939572

Inhibitor of stearoyl-CoA desaturase SCD1 with IC50 of 6.3 nM, as measured in the SCD1-expressing human microsomes.  A 939572 exhibited anticancer activity as it reduced cell proliferation and triggered cell killing in human non-small cell lung carcinoma cells. A 939572 inhibited tumour growth in an in vivo model for gastric carcinoma and reduced the oleic acid:stearic acid ratio in mouse liver and plasma.

Technical Data

CAS No: 1032229-33-6
Synonyms: 4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Product Code: BA162794
Chemical Formula: C20H22ClN3O3
Molecular Weight: 387.86

References


  • Roongta et al (2011). Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy. Molecular Cancer Research 9(11):1551-61.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1032229-33-6
Synonyms:
4-(2-Chlorophenoxy)-N-[3-[(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide
Chemical Formula:
Molecular Weight:
387.86
Product Structure
References:
1. Roongta et al (2011). Cancer Cell Dependence on Unsaturated Fatty Acids Implicates Stearoyl-CoA Desaturase as a Target for Cancer Therapy. Molecular Cancer Research 9(11):1551-61.
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