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FC09794
BIO-X

Calcitriol

Calcitriol is a steroid hormone, vitamin D metabolite and agonist of vitamin D receptor (VDR), also known as calcitriol receptor. It regulates absorption of calcium from intestine, resorption of bone calcium and calcium excretion via kidneys. This compound also controls cell cycle, promotes cell differentiation, triggers apoptosis and acts as anti-inflammatory factor within the tumor microenvironment. It has anti-proliferative effects in malignant epithelial cells and in tumour-derived endothelial cells (TDEC). Also, it is a potent inhibitor of retinal neoangiogenesis in vitro.

Technical Data

CAS No: 32222-06-3
Synonyms: 1a,25-Dihydroxycholecalciferol; 1a,25-Dihydroxyvitamin D3; Rocaltrol
Product Code: FC09794
MDL No: MFCD00867079
Chemical Formula: C27H44O3
Molecular Weight: 416.65

References


  • Diaz et al., 2015. Mechanistic Effects of Calcitriol in Cancer Biology. Nutrients 7(6):5020-50.
  • Chung et al., 2009. Role of Vitamin D Receptor in the Antiproliferative Effects of Calcitriol in Tumor-Derived Endothelial Cells and Tumor Angiogenesis In vivo. Cancer Res 69(3):967-75.
  • Albert et al., 2007. Calcitriol Is a Potent Inhibitor of Retinal Neovascularization. Invest Ophthalmol Vis Sci 48(5):2327-34.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
32222-06-3
Synonyms:
1a,25-Dihydroxycholecalciferol
1a,25-Dihydroxyvitamin D3
Rocaltrol
MDL No:
MFCD00867079
Chemical Formula:
Molecular Weight:
416.65
Product Structure
References:
1. Diaz et al., 2015. Mechanistic Effects of Calcitriol in Cancer Biology. Nutrients 7(6):5020-50.
2. Chung et al., 2009. Role of Vitamin D Receptor in the Antiproliferative Effects of Calcitriol in Tumor-Derived Endothelial Cells and Tumor Angiogenesis In vivo. Cancer Res 69(3):967-75.
3. Albert et al., 2007. Calcitriol Is a Potent Inhibitor of Retinal Neovascularization. Invest Ophthalmol Vis Sci 48(5):2327-34.
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