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BS165496
BIO-X

SB 334867 HCl

A non-peptide antagonist of orexin receptors, selective for subtype OX1 over OX2 (50-fold more). Systemic administration in vivo inhibits orexin-A induced grooming and feeding. Elicits sedative and anorectic effects in vivo. Reduces intake of food in rats, induced by orexin-A or overnight fasting.

Technical Data

CAS No: 249889-64-3
Synonyms: SB 334867A; N-(2-methyl-6-benzoxazolyl)-N'-1,5-napthyridin-4-yl)urea monohydrochloride
Product Code: BS165496
Chemical Formula: C17H13N5O2·HCl
Molecular Weight: 355.78

Literature

References
  • Haynes AC et al (2000). A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96(1-2):45-51.
  • Duxon MS et al (2001). Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology (Berl) 153(2):203-9.
  • Smart D et al (2001). SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132(6):1179-82.

Solubility

Stability

Datasheets


SB 334867 HCl - Bio-X

CAS No:
249889-64-3
Synonyms:
SB 334867A
N-(2-methyl-6-benzoxazolyl)-N'-1,5-napthyridin-4-yl)urea monohydrochloride
Chemical Formula:
Molecular Weight:
355.78
Product Structure
References:
1. Haynes AC et al (2000). A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul Pept 96(1-2):45-51.
2. Duxon MS et al (2001). Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology (Berl) 153(2):203-9.
3. Smart D et al (2001). SB-334867-A: the first selective orexin-1 receptor antagonist. Br J Pharmacol 132(6):1179-82.

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