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BS167477
BIO-X

SU 0268 NEW

Inhibitor of 8-oxoguanine DNA glycosylase OGG1 with IC50 of 0.059 μM and excellent specificity over other DNA repair enzymes. OGG1 and its substrate 8-oxoguanine are involved in mutagenesis, genotoxicity, inflammation and cancer. The compound can cause accumulation of 8-oxoguanine in DNA in vitro and is a potent tool for the study of OGG1 biology.

Technical Data

CAS No: 2210228-45-6
Synonyms: SU0268; 4'-​[[[1-​(cyclopropylcarbonyl​)​-​1,​2,​3,​4-​tetrahydro-​7-​quinolinyl]​amino]​sulfonyl]​-[1,​1'-​Biphenyl]​-​3-​carboxamide
Product Code: BS167477
Chemical Formula: C26H25N3O4S
Molecular Weight: 475.56

References


  • Tahara et al (2018). Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of the American Chemical Society 140(6):2105-2114.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
2210228-45-6
Synonyms:
SU0268
4'-​[[[1-​(cyclopropylcarbonyl​)​-​1,​2,​3,​4-​tetrahydro-​7-​quinolinyl]​amino]​sulfonyl]​-[1,​1'-​Biphenyl]​-​3-​carboxamide
Chemical Formula:
Molecular Weight:
475.56
Product Structure
References:
1. Tahara et al (2018). Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase. Journal of the American Chemical Society 140(6):2105-2114.
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