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BT164468

Tianeptine sodium - Bio-X

Full agonist of the μ-opioid receptor (MOR) with Ki of 383 nM. It also weakly agonizes the δ-opioid receptor (DOR) with a Ki >10 μM. Tianeptine has antidepressant effects but can also regulate neuroplasticity in the amygdala and stress-induced release of glutamate. It can generate analgesia and reward, typical opiate-like behavioural effects, but does not induce tolerance or withdrawal.

Technical Data

CAS No: 30123-17-2
Synonyms: 7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt; S-1574; Stablon
Product Code: BT164468
MDL No: MFCD00879851
Chemical Formula: C21H24ClN2NaO4S
Molecular Weight: 458.93

References


  • Samuels et al., 2017. The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor. Neuropsychopharmacology 42(10):2052-2063.
  • Gassaway et al., 2014. The atypical antidepressant and neurorestorative agent tianeptine is a mu-opioid receptor agonist. Transl Psychiatry 4: e411.
  • McEwen et al., 2010. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry 15: 237–249.

Solubility

Stability

Further Information


Datasheets


Tianeptine sodium - Bio-X

CAS No:
30123-17-2
Synonyms:
7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide sodium salt
S-1574
Stablon
MDL No:
MFCD00879851
Chemical Formula:
Molecular Weight:
458.93
Product Structure
References:
1. Samuels et al., 2017. The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor. Neuropsychopharmacology 42(10):2052-2063.
2. Gassaway et al., 2014. The atypical antidepressant and neurorestorative agent tianeptine is a mu-opioid receptor agonist. Transl Psychiatry 4: e411.
3. McEwen et al., 2010. The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation. Mol Psychiatry 15: 237–249.

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