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NM30233

2-Methylthio-N6-isopentenyladenosine NEW

A nucleoside analogue of adenosine that arises from post-transcriptional modification. In humans, this is mediated by the enzyme CDK5RAP1 in mitochondrial transfer RNA (tRNA) at amino acid 37. Deficiency for this modification, for example due to CDK5RAP1 deficiency, leads to impaired mitochondrial protein synthesis. This has implications for mitochondrial diseases, as well as cancer, type II diabetes and vitiligo. Synthetic ms2i6A can be used to raise monoclonal antibodies against this nucleotide in vivo

Technical Data

CAS No: 20859-00-1
Synonyms: 2-methylthio-6-(3,3-dimethylallylamino)-9-b-D-ribofuranosylpurine
Product Code: NM30233
Chemical Formula: C16H23N5O4S
Molecular Weight: 381.45

References


  • Fakruddin M et al (2017). Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. Nucleic Acids Res 45(20):11954-11961.
  • Xiong J et al (2018). CDK5RAP1 targeting NF-κB signaling pathway in human malignant melanoma A375 cell apoptosis. Oncol Lett 15(4):4767-4774.
  • de Crécy-Lagard et al (2019). Matching tRNA modifications in humans to their known and predicted enzymes. Nucleic Acids Research, gkz011, doi: 10.1093/nar/gkz011.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
20859-00-1
Synonyms:
2-methylthio-6-(3,3-dimethylallylamino)-9-b-D-ribofuranosylpurine
Chemical Formula:
Molecular Weight:
381.45
Product Structure
References:
1. Fakruddin M et al (2017). Cdk5rap1-mediated 2-methylthio-N6-isopentenyladenosine modification is absent from nuclear-derived RNA species. Nucleic Acids Res 45(20):11954-11961.
2. Xiong J et al (2018). CDK5RAP1 targeting NF-κB signaling pathway in human malignant melanoma A375 cell apoptosis. Oncol Lett 15(4):4767-4774.
3. de Crécy-Lagard et al (2019). Matching tRNA modifications in humans to their known and predicted enzymes. Nucleic Acids Research, gkz011, doi: 10.1093/nar/gkz011.
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