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BP164272
BIO-X

Pioglitazone hydrochloride

Agonist of peroxisome proliferator-activated receptor-γ (PPARγ), useful for the treatment and prevention of type 2 diabetes mellitus. It belongs to the class of thiazolidinediones (TZDs), which increase insulin sensitivity and glucose uptake in peripheral tissues. It reduces the risk of cardiovascular disease and was shown to atheroprotective and anti-inflammatory effects in animal models.

Technical Data

CAS No: 112529-15-4
Synonyms: 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride
Product Code: BP164272
MDL No: MFCD04975446
Chemical Formula: C19H20N2O3S·HCl
Molecular Weight: 392.90

References


  • Soccio et al., 2014. Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes. Cell Metabolism 20(4):573-91.
  • Omae et al., 2011. Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Investigative Ophthalmology and Investigative Science 52(9):6749-56.

Solubility

Stability

Further Information


Datasheets


CAS No:
112529-15-4
Synonyms:
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride
MDL No:
MFCD04975446
Chemical Formula:
Molecular Weight:
392.90
Product Structure
References:
1. Soccio et al., 2014. Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes. Cell Metabolism 20(4):573-91.
2. Omae et al., 2011. Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist, induces dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels. Investigative Ophthalmology and Investigative Science 52(9):6749-56.

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