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BV168436
BIO-X

Valiglurax NEW

Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor mGlu4. Valiglurax is orally bioavailable and CNS-penetrant mGlu4 PAM in preclinical development for the Parkinson’s disease therapy and alleviation of the motor symptoms.

Technical Data

CAS No: 1976050-09-5
Synonyms: N-1H-Pyrazolo[3,4-b]pyridin-3-yl-1-(trifluoromethyl)-6-isoquinolinamine; VU 2957; VU2957
Product Code: BV168436
Chemical Formula: C16H10F3N5
Molecular Weight: 329.28

References


  • Panarese et al (2019). Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease. ACS Medicinal Chemistry Letters 10:255−260.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
1976050-09-5
Synonyms:
N-1H-Pyrazolo[3,4-b]pyridin-3-yl-1-(trifluoromethyl)-6-isoquinolinamine
VU 2957
VU2957
Chemical Formula:
Molecular Weight:
329.28
Product Structure
References:
1. Panarese et al (2019). Discovery of VU2957 (Valiglurax): An mGlu4 Positive Allosteric Modulator Evaluated as a Preclinical Candidate for the Treatment of Parkinson’s Disease. ACS Medicinal Chemistry Letters 10:255−260.
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