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FV28720
BIO-X

MDL 100907 NEW

Selective antagonist of the serotonin receptors 5-HT2A with subnanomolar affinity. The compound has clozapine-like anti-psychotic properties and more favourable CNS safety profile than traditional anti-psychotics. MDL 100907 has been used in studies on antisocial behaviour in mice and shown that the blockage of 5-HT2A receptors leads to decreased post-traumatic aggression and bradycardia.

Technical Data

CAS No: 139290-65-6
Synonyms: (a-R)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol; M 100907; Volinanserin
Product Code: FV28720
MDL No: MFCD00909060
Chemical Formula: C22H28FNO3
Molecular Weight: 373.46

References


  • Sorensen et al., 1993. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacology & Exper Therapeutics 266 (2) 684-691.
  • Kehne et al., 1996. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J Pharmacology & Exper Therapeutics 277 (2) 968-981.
  • Godar et al (2019). Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation. Neuropharmacology [In Press].

Solubility

Stability

Further Information


Datasheets

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MSDS: View

MDL 100907 - Bio-X

CAS No:
139290-65-6
Synonyms:
(a-R)-a-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
M 100907
Volinanserin
MDL No:
MFCD00909060
Chemical Formula:
Molecular Weight:
373.46
Product Structure
References:
1. Sorensen et al., 1993. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: behavioral, electrophysiological and neurochemical studies. J Pharmacology & Exper Therapeutics 266 (2) 684-691.
2. Kehne et al., 1996. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J Pharmacology & Exper Therapeutics 277 (2) 968-981.
3. Godar et al (2019). Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation. Neuropharmacology [In Press].
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