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FA64929
BIO-X

A 922500 - Bio-X

Inhibits human and mouse diacylglycerol O-acyltransferase 1 (DGAT-1) with IC50 values of 9 and 22 nM, respectively. Selective for DGAT-1 over DGAT-2 (IC50 = 53 µM), acyl coenzyme A transferase (IC50 = 296 µM) and other acyltransferases. Reduces plasma and liver triglycerides, FFA, chylomicron secretion and increases HDL cholesterol in vivo.

Technical Data

CAS No: 959122-11-3
Product Code: FA64929
MDL No: MFCD12828780
Chemical Formula: C26H24N2O4
Molecular Weight: 428.48

Literature

References
  • Zhao G et al (2008). Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 51(3):380-3.
  • King AJ et al (2009). Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. J Pharmacol Exp Ther 330(2):526-31.

Solubility

Stability

Datasheets


A 922500 - Bio-X

CAS No:
959122-11-3
MDL No:
MFCD12828780
Chemical Formula:
Molecular Weight:
428.48
Product Structure
References:
1. Zhao G et al (2008). Validation of diacyl glycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J Med Chem 51(3):380-3.
2. King AJ et al (2009). Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster. J Pharmacol Exp Ther 330(2):526-31.

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