Availability
0
Your Basket is Empty
BB162775
BIO-X

BIO

Specific inhibitor of glycogen synthase kinase 3 (GSK-3) with IC50 in low nanomolar range. Studies showed that BIO maintains self-renewal in embryonic stem cells (ESCs) as well as increases activity of β-catenin. In neonatal cardiomyocytes, BIO promotes cell cycle by stimulating cell entry into S phase as well as cytokinesis. In germline stem cells from female mice (FGSCs), BIO promoted proliferation and maintenance of FGSCs by activating β-catenin and up-regulating E-cadherin.

Technical Data

CAS No: 667463-62-9
Synonyms: (2'Z,3'E)-6-Bromoindirubin-3'-oxime
Product Code: BB162775
Chemical Formula: C16H10BrN3O2
Molecular Weight: 356.17

References


  • Tseng et al (2006). The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chemistry and Biology 13(9):957-963.
  • Hu et al (2012). GSK3 inhibitor‐BIO regulates proliferation of female germline stem cells from the postnatal mouse ovary. Cell Proliferation 45:287-298.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
667463-62-9
Synonyms:
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
Chemical Formula:
Molecular Weight:
356.17
Product Structure
References:
1. Tseng et al (2006). The GSK-3 Inhibitor BIO Promotes Proliferation in Mammalian Cardiomyocytes. Chemistry and Biology 13(9):957-963.
2. Hu et al (2012). GSK3 inhibitor‐BIO regulates proliferation of female germline stem cells from the postnatal mouse ovary. Cell Proliferation 45:287-298.
Click for Specification
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...