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BE170203
BIO-X

ES9-17 NEW

Inhibitor of clathrin-mediated endocytosis (CME) and ligand to the clathrin heavy chain (CHC). ES9-17 is an inhibitor of the CHC function with EC50 of 13 μM in plant model Arabidopsis thaliana. ES9-17 is a non-protonophoric CME inhibitor and it does not alter the cytoplasmic pH levels substantially. In a mammalian cell line HeLa, ES9-17 reduced the uptake of transferrin, which is a CME-driven process.

Technical Data

CAS No: 55854-43-8
Synonyms: 5-Bromo-N-phenyl-2-thiophenesulfonamide; ES9 17
Product Code: BE170203
Chemical Formula: C10H8BrNO2S2
Molecular Weight: 318.21

References


  • Dejonghe et al (2019). Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology 15(6):641-649.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
55854-43-8
Synonyms:
5-Bromo-N-phenyl-2-thiophenesulfonamide
ES9 17
Chemical Formula:
Molecular Weight:
318.21
Product Structure
References:
1. Dejonghe et al (2019). Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology 15(6):641-649.
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