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BR164589

Isotretinoin

An endogenous retinoic acid receptor (RAR) agonist that upregulates forkhead box class O (FoxO) transcription factor. Suppresses activity and proliferation of sebaceous glands. Used for treating nodulocystic acne. Induces differentiation, neurite outgrowth and inhibits proliferation of neuroblastoma cells. A potential chemopreventive agent in non-small cell lung cancer, head and neck squamous cell carcinoma and neuroblastoma. 

Technical Data

CAS No: 4759-48-2
Synonyms: 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2Z,4E,6E,8E-nonatetranenoic acid; Isotretinoin; 13-cis-Vitamin A acid
Product Code: BR164589
MDL No: MFCD00871167
Chemical Formula: C20H28O2
Molecular Weight: 300.44

References


  • Layton AM et al (1993). Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment. Br J Dermatol 129(3):292-6.
  • Melnik BC (2011). Isotretinoin and FoxO1. Dermatoendocrinol 3(3): 141–165.
  • Sonawane P et al (2014). Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br J Pharmacol 171(23):5330-44.

Solubility

Stability

Further Information


Datasheets


Isotretinoin

CAS No:
4759-48-2
Synonyms:
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2Z,4E,6E,8E-nonatetranenoic acid
Isotretinoin
13-cis-Vitamin A acid
MDL No:
MFCD00871167
Chemical Formula:
Molecular Weight:
300.44
Product Structure
References:
1. Layton AM et al (1993). Isotretinoin for acne vulgaris--10 years later: a safe and successful treatment. Br J Dermatol 129(3):292-6.
2. Melnik BC (2011). Isotretinoin and FoxO1. Dermatoendocrinol 3(3): 141–165.
3. Sonawane P et al (2014). Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br J Pharmacol 171(23):5330-44.

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