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BA170096
BIO-X

Ac4GlcNAcF3

Potent, selective and cell-permeable tool for modulation of O-GlcNAcylation. Ac4GlcNAcF3 is a dual modulator of O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ac4GlcNAcF3 perturbates the GlcNAc cycling as OGT can incorporate GlcNAcF3 onto proteins but subsequently, it cannot be removed by OGA. In a mouse embryogenic fibroblast cell line, Ac4GlcNAcF3 increased the level of protein O-GlcNAcylation.

Technical Data

CAS No: 137766-83-7
Synonyms: 2- Deoxy-2-[(2,2,2-trifluoroacetyl)amino]-D-glucopyranose-1,3,4,6-tetraacetate
Product Code: BA170096
Chemical Formula: C16H20F3NO10
Molecular Weight: 443.33

References


  • Wang et al (2019). Ac4GlcNAcF3, an OGT-tolerated but OGA-resistant regulator for O-GlcNAcylation. Biorganic and Medicinal Chemistry Letters 29:802-805.

Solubility

Stability

Further Information


Datasheets

Specification: View
MSDS: View

CAS No:
137766-83-7
Synonyms:
2- Deoxy-2-[(2,2,2-trifluoroacetyl)amino]-D-glucopyranose-1,3,4,6-tetraacetate
Chemical Formula:
Molecular Weight:
443.33
Product Structure
References:
1. Wang et al (2019). Ac4GlcNAcF3, an OGT-tolerated but OGA-resistant regulator for O-GlcNAcylation. Biorganic and Medicinal Chemistry Letters 29:802-805.
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