Availability
0
Your Basket is Empty
BG168610
BIO-X

GK 563 NEW

Potent inhibitor of the calcium-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM. GK 563 is 22000 times more active against GVIA iPLA2 than against the cytoplasmic phospholipase GVIA cPLA2. In β pancreatic cells from rat, GK 563 was shown to inhibit the β cell apoptosis when co-administered with pro-inflammatory cytokines.

Technical Data

CAS No: 1983928-04-6
Synonyms: trans-3-(4- Phenylbutyl)-4-propyl-2-oxetanone
Product Code: BG168610
Chemical Formula: C16H22O2
Molecular Weight: 246.34

References


  • Dedaki et al (2019). β‑Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β‑Cell Apoptosis. Journal of Medicinal Chemistry 62:2916−2927.

Solubility

Stability

Further Information


Datasheets

MSDS: View

CAS No:
1983928-04-6
Synonyms:
trans-3-(4- Phenylbutyl)-4-propyl-2-oxetanone
Chemical Formula:
Molecular Weight:
246.34
Product Structure
References:
1. Dedaki et al (2019). β‑Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β‑Cell Apoptosis. Journal of Medicinal Chemistry 62:2916−2927.
Click for MSDS

For requirements greater than the catalogue prepacks email: enquiries@carbosynth.com

Custom Synthesis

For custom synthesis or special requests email: enquiries@carbosynth.com, call +44 (0)1635 578444 or fill out our contact form

Please Wait...