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DNA Cross Linkers

These compounds cause DNA interstrand crosslinks that include natural alkylating agents such as mitomycin C or synthetic agents, such as platinum compounds. These DNA lesions, if left unrepaired, lead to disruption of DNA replication and transcription and therefore have genotoxic and cytotoxic consequences. DNA cross linkers thus have therapeutic applications in treating solid tumors, as well as autoimmune diseases and dermatological conditions. The DNA cross linkers available from Biosynth Carbosynth are listed below.

Code Cas No Product Description
BA171670 1430208-73-3


Rac1 inhibitor; blocks Rac1-P-Rex1 interaction BIO-X
BA166127 1384424-80-9

A 1070722

Inhibitor of GSK-3 kinase; reduces phosphorylation of Tau protein BIO-X
BA164085 1982372-88-2

A 196

Inhibitor of histone-lysine N-methyltransferase SUV420H1 and SUV420H2 BIO-X
FA17735 78957-85-4

A 3

Inhibitor of PKA kinase BIO-X
BA166476 1889279-16-6

A 485

Histone acetyltransferase inhibitor of p300/CBP; anti-proliferative BIO-X
BA41291 1166227-08-2

A 66 NEW

Inhibitor of PI3K kinase; anti-cancer agent; arrhythmogenic BIO-X
FA16147 844499-71-4

A 769662

Activator of AMP-activated protein kinase (AMPK) BIO-X
BA162484 909910-43-6

A 83-01

Inhibitor of TGF-β type I receptor ALK5 kinase BIO-X
FA64929 959122-11-3

A 922500

DGAT-1 enzyme antagonist BIO-X
BA162794 1032229-33-6

A 939572

Inhibitor of stearoyl-CoA desaturase SCD1 BIO-X
BA166584 1037826-77-9

A 953227

Calpain antagonist BIO-X
FA100934 934162-61-5

A 966492

Inhibitor of PARP enzyme BIO-X
BA162479 915385-81-8

ABC 294640

FE103812 1231929-97-7


Inhibitor of cyclin-dependent kinases CDK4 and CDK6 BIO-X
FA159696 1231930-82-7

Abemaciclib mesylate

Inhibits cyclin-dependent kinase 4 and 6 (CDK4 and CDK6); antineoplastic BIO-X
BA164060 154229-19-3


CYP17 enzyme inhibitor BIO-X
BA164133 154229-18-2

Abiraterone acetate

CYP17 enzyme inhibitor BIO-X

Abiraterone ethyl ether

CYP17 enzyme inhibitor BIO-X
FA166721 1310726-60-3

ABT 494

Inhibitor of Janus kinase JAK-1 BIO-X
FF100506 154355-76-7

ABT 761

Inhibitor of 5-lipoxygenase BIO-X
BA167497 1446817-84-0

ABX 1431

Inhibits monoacylglycerol lipase BIO-X
BA170096 137766-83-7


Modulator of O-GlcNAcylation; increases protein O-GlcNAc levels BIO-X
FA138815 1420477-60-6


Inhibitor of the Bruton tyrosine kinase BIO-X
FA101029 870281-34-8


 Selective PI3Kδ inhibitor BIO-X
BA164135 89796-99-6


Cyclooxygenase inhibitor; NSAID BIO-R
BA164806 1316214-52-4

ACY 1215

Inhibitor of histone deacetylase 6 BIO-X
BA164139 142340-99-6

Adefovir dipivoxil

Anti-viral; reverse transcriptase inhibitor BIO-X
FA17224 791828-58-5


Dual inhibitor of ADAM10 and ADAM17 metalloproteases BIO-X
FA17229 497839-62-0

AEE 788

Dual inhibitor of EGFR and VEGR receptor phosphorylation; anti-metastatic BIO-X
FA103643 439081-17-1


Irreversible inhibitor of ErbB1, ErbB2/HER2 and ErbB4; less active enantiomer BIO-X
BA164141 850140-72-6


Irreversible inhibitor of ErbB1, ErbB2/HER2 and ErbB4 receptor tyrosine kinases BIO-X
BA162012 850140-73-7

Afatinib dimaleate

Irreversible inhibitor of ErbB1, ErbB2/HER2 and ErbB4 receptor tyrosine kinases BIO-X
BA166066 1047644-62-1


Inhibitor of pan-AKT BIO-X
FA145491 1448347-49-6

AG 120

Inhibits mutant form of IDH-1 enzyme; anti-proliferative BIO-X
FA145490 1446502-11-9

AG 221

Inhibitor of isocitrate dehydrogenase 2 BIO-X
FC17241 134036-52-5

AG 490

Inhibits EGFR, STAT3, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK tyrosine kinases BIO-X
BA166653 681281-88-9

Akt Inhibitor IV

Inhibitor of Akt kinase
FA17261 1483-07-4

L-Albizziin SALE

Inhibitor of glutaminase; glutamine analogue
A-4650 1483-07-4


FA64934 1256589-74-8

Alectinib hydrochloride

Active product of vitamin A metabolism BIO-X
BA164144 121268-17-5

Alendronic acid monosodium salt trihydrate

Farnesyl diphosphate synthase inhibitor; inhibits bone resorption BIO-R
BA165582 1245916-14-6


Antibody Monoclonal antibody to PCSK9 ; inhibitor of proprotein convertase PCSK9
BA164146 173334-58-2

Aliskiren hemifumarate

Non-peptide renin inhibitor; anti-hypertensive BIO-X
FA137645 1345847-93-9


Inhibitor of MET, TIE2 and VEGFR2 kinases BIO-X
BA164807 1186206-79-0


Eph receptor tyrosine kinase inhibitor BIO-X
BA167876 1442684-77-6

AM 2394

Glucokinase activator BIO-X
BA166478 179044-97-4

AMG 18 hydrochloride

Inhibitor of endonuclease IRE1α BIO-X
FA137646 1608125-21-8

AMG 319

FA64937 913376-83-7

AMG 458

c-Met receptor tyrosine kinase inhibitor BIO-X
FA137647 1401033-86-0

AMG 925

Dual inhibitor of FLT3 and CDK4 kinases BIO-X
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