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Coupling Agents

Coupling agents are widely used for amide and ester formation, especially for solid-phase peptide synthesis, as they facilitate bond formation without becoming part of the linkage. In synthetic organic chemistry, compounds containing the carbodiimide functionality act as dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Additives, such as N-hydroxybenzotriazole or N-hydroxysuccinimide, are often added to increase yields and decrease side reactions.

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Code Cas No Product Description
FB01762 56602-33-6

BOP

FB15685 164298-25-3

BTFFH

Peptide coupling reagent; does not form volatile or toxic byproducts
FB45526 1433-27-8

1-(tert-Butyl)-3-ethylcarbodiimide

Coupling agent for guanylation of amines; used for ketene cyclo-addition
FC02706 530-62-1

N,N'-Carbonyl diimidazole

Coupling agent; also used to make lead sequestering agents and β-enamino acids
FC160903 181517-09-9

1,1'-Carbonyldiimidazole-13C

Isotopic labelled coupling reagent for mechanistic studies
FC19968 37091-73-9

2-Chloro-1,3-dimethylimidazolinium chloride

Used in synthesis of glycosyl oxazolines and azides; peptide linked to sugars
FC07101 3140-73-6

2-Chloro-4,6-dimethoxy-1,3,5-triazine

Peptide coupling agent
FC15427 1075198-30-9

4-{{[(1-Cyano-2-ethoxy-2-oxoethylidene)amino]oxayl] (dimethylamino)methylene]-hexafluorophosphate

A safe coupling agent in phosphonamidation; used in peptides synthesis
FC55888 2491-17-0

N-Cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl-p-toluenesulfonate

Water-soluble coupling reagent for peptide synthesis used without base catalysis
FD05508 538-75-0

1,3-Dicyclohexyl carbodiimide

Used in peptide coupling, esterification and invert 2nd alcohol stereochemistry
FD02073 693-13-0

1,3-Diisopropylcarbodiimide

Coupling agent for peptides, nucleic acids and asymmetric bis alkyl carbonates
FD02693 1892-57-5

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Used in combination with N-hydroxysuccinimide in amide coupling reaction
FD05800 25952-53-8

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Water soluble reagent; carboxyl activating agent; used in immunoconjugates
FD03847 22572-40-3

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide methiodide

Water soluble crosslinking agent
FD15692 74124-79-1

N,N'-Disuccinimidyl carbonate

FH09243 148893-10-1

HATU

Coupling agent with fast reaction rate; catalyses selective acylation
FH07095 94790-37-1

HBTU

High yielding for peptide synthesis; suitable in both solid and solution phase
FH15560 330645-87-9

HCTU

Stable coupling agent for hindered substrates; faster reaction rate than HBTU
FP15550 128625-52-5

PyBOP

FT07096 125700-67-6

TBTU

Versatile agent in solid-phase peptide synthesis with low degree of racemisation
FT35332 164298-23-1

TFFH

Coupling agent for peptide synthesis; non-hygroscopic air stable salt
FT15567 136849-72-4

TOTU

FT15580 105832-38-0

TSTU

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